Heritability estimation in case-control studies
نویسندگان
چکیده
منابع مشابه
Narrowing the gap on heritability of common disease by direct estimation in case-control GWAS
paragraph One of the major developments in recent years in the search for missing heritability of human phenotypes is the adoption of linear mixed-effects models (LMMs) to estimate heritability due to genetic variants which are not significantly associated with the phenotype 1. A variant of the LMM approach has been adapted to case-control studies and applied to many major diseases 2–5 , succes...
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ژورنال
عنوان ژورنال: Electronic Journal of Statistics
سال: 2018
ISSN: 1935-7524
DOI: 10.1214/18-ejs1424